Dr. Vinata B Lokeshwar's lab at Augusta University focuses on improving treatments for high-risk bladder cancer. Their research investigates how to overcome resistance to chemotherapy, specifically the drug Gemcitabine, by targeting a newly identified enzyme called Chase. The lab aims to develop combination therapies that enhance the effectiveness of existing treatments and to identify biomarkers that help predict patient responses to these therapies.

Dr. Gang Zhou's lab at Augusta University focuses on enhancing immunotherapy techniques, particularly adoptive T-cell therapy (ACT). The lab investigates how specific signaling pathways can be manipulated to improve the ability of CD4 T cells to fight cancers, especially by promoting their persistence and multifunctionality. Their research aims to develop new approaches that could make ACT more effective for solid tumors, potentially leading to better patient outcomes.

Dr. Yan Cui's research lab focuses on understanding how a specific pathway in the immune system affects head and neck cancers, particularly those that arise due to tobacco and alcohol use. The team studies how certain molecules in the tumor environment, like CD73 and its receptor A2BR, help tumors evade the immune system, making them harder to treat. By exploring these interactions, the lab aims to develop new therapies that can enhance immune responses against these aggressive cancers.