Dr. Joe R. Delaney's research at the Medical University of South Carolina focuses on understanding how certain genetic changes in tumors can affect their behavior and response to treatment. Specifically, his lab investigates a group of proteins called metallothioneins, which are involved in regulating metals in cells and can influence tumor development, especially in ovarian cancer. This research aims to find new ways to target these genetic vulnerabilities in cancer cells, ultimately leading to improved therapies for patients.

Dr. John P. O'Bryan's lab focuses on understanding how certain proteins, called RAS, contribute to cancer development. They are exploring new ways to inhibit these proteins using innovative synthetic molecules called monobodies, which can bind to RAS with high specificity. By studying how these molecules affect RAS function, the lab aims to identify new strategies for cancer therapy that directly target RAS mutations.