Dr. Wenbo Li's lab at the University of Texas Health Science Center focuses on understanding the role of enhancer RNAs in regulating brain genes and their connections to Alzheimer's disease. By investigating how these noncoding RNAs function and affect gene expression, the lab aims to uncover new molecular mechanisms behind Alzheimer's, which could lead to better diagnostic tools and treatments.

Dr. Vasanthi Jayaraman's lab focuses on understanding how different types of glutamate receptors work in the brain, especially in relation to controlling movement and cognitive functions such as learning and memory. By using advanced techniques like single-molecule FRET and various biochemical methods, the lab investigates the complex interactions and structural changes within these receptors, aiming to uncover how they operate in both healthy and disease conditions. Their work could provide insights into the mechanisms underlying neurological disorders like strokes and Parkinson's disease.

Dr. Harry Karmouty-Quintana's lab at the University of Texas Health Science Center focuses on understanding how ribosome dysfunction contributes to severe lung diseases, particularly interstitial lung disease associated with systemic sclerosis. They investigate how changes in ribosome production affect cell behavior and lead to excessive scarring in the lungs, which can be fatal. The ultimate goal is to uncover new treatment strategies for patients suffering from lung fibrosis.

Dr. Irina Serysheva's lab focuses on understanding how calcium signaling in cells is regulated, particularly through a protein called inositol 1,4,5-trisphosphate receptor (IP3R). By studying how this receptor works at a molecular level, the lab aims to uncover its role in various diseases, including neurodegenerative disorders like Alzheimer's disease. The research combines advanced techniques in structural biology and biophysics to develop insights that could lead to new treatments for conditions caused by calcium signaling dysfunction.

Dr. Tingting Weng Mills' lab at the University of Texas Health Science Center focuses on understanding how macrophages, a type of immune cell, play a role in lung injuries like Acute Respiratory Distress Syndrome (ARDS). They explore the function of a specific protein called NUDT21 that influences RNA processing in these cells, potentially leading to new treatments for ARDS. By studying how NUDT21 is regulated under conditions like low oxygen, the lab aims to find innovative ways to control inflammation and improve patient outcomes.