Dr. Junji Iwahara's lab at the University of Texas Medical Branch focuses on understanding how proteins interact with DNA, which is vital for regulating gene expression and maintaining genomic integrity. The lab uses advanced techniques like nuclear magnetic resonance (NMR) to study the dynamic processes through which DNA-binding proteins locate and recognize their target sites on DNA. These insights are crucial for developing new therapies for diseases linked to dysfunctional DNA-binding proteins.

Dr. Thomas James Smith's lab at the University of Texas Medical Branch Galveston focuses on understanding how noroviruses evade the immune system. They investigate the structural dynamics of norovirus capsids, which can change shape to avoid recognition by antibodies. By studying the mouse norovirus model, the lab aims to provide insights that could lead to effective vaccines and treatments for norovirus infections, which cause significant illness worldwide, especially in young children and older adults.

Dr. Sanja Sever's research focuses on understanding how specific proteins, particularly the proteolytic fragment of the soluble urokinase receptor (suPAR), contribute to kidney disease and diabetes. By studying how this fragment affects both kidney podocytes and pancreatic beta-cells, her lab aims to uncover new therapeutic targets that could help treat chronic kidney disease and Type 1 diabetes. The work is particularly relevant as these conditions are on the rise and can lead to serious health complications.