Michael Buck's lab at the University of Buffalo studies how transcription factors (TFs) interact with DNA in our cells. They focus on understanding the rules that govern how these proteins bind to chromatin, which is the material that makes up our chromosomes, particularly when it is tightly packed. By exploring these interactions, the lab seeks to uncover insights into gene expression, which is crucial for normal development and understanding diseases.

Dr. Gabriela K. Popescu's research lab focuses on understanding how NMDA receptors function in the brain. These receptors play a crucial role in controlling communication between nerve cells, which is vital for learning and memory. By delving into the molecular details of how these receptors activate, the lab aims to discover new treatments for diseases like Alzheimer's and Parkinson's, particularly for patients with specific genetic variants.