Dr. Gopal Thinakaran's lab focuses on understanding the role of a protein called BIN1 in Alzheimer's disease. They study how BIN1 influences inflammation and the progression of neurodegenerative processes related to amyloid and tau proteins in the brain. The research involves using specific mouse models to investigate the mechanisms through which BIN1 impacts brain health and disease, with the ultimate goal of uncovering potential therapeutic targets for Alzheimer's.

Dr. Yu Chen's lab at the University of South Florida focuses on the bacteria Clostridioides difficile, which is a major cause of hospital infections. The lab studies how certain proteins in the bacteria help it resist antibiotics and contribute to its ability to produce resilient spores. By understanding these mechanisms, the lab aims to develop new treatments to combat recurring infections caused by this pathogen.

Dr. Subhra Mohapatra's lab at the University of South Florida focuses on understanding the long-term neurological effects of COVID-19, particularly how the virus impacts tau proteins related to neurodegenerative diseases like Alzheimer's. The lab uses mouse models to investigate how aging and COVID-19 infection can lead to neurological issues, aiming to find new ways to prevent or treat these conditions. Through their research, they hope to identify specific molecular targets that can be manipulated to reduce the negative effects of COVID-19 on the brain.

Dr. Laura J. Blair's lab at the University of South Florida studies the role of a protein called FKBP51 in Alzheimer's disease, particularly how it relates to neuropsychiatric symptoms like depression. The lab uses mouse models to investigate whether modifying FKBP51 can protect against nerve cell damage linked to tau protein accumulation. This research could enhance understanding of Alzheimer's progression and identify potential therapeutic targets for improving mental health in affected patients.

Dr. Zhiming Ouyang's lab at the University of South Florida focuses on understanding how the Lyme disease-causing bacterium Borrelia burgdorferi regulates its virulence. By studying a protein called BosR, the lab aims to reveal how this bacterium adapts to its environments, such as ticks and mammals, and uses unique mechanisms to control its infection capabilities. Insights from this research may lead to new treatments or vaccines for Lyme disease, highlighting its importance for public health.