Dr. Kwangjin Cho's lab at Wright State University focuses on understanding how specific lipids at the Golgi complex influence the composition and organization of the plasma membrane in human cells. By examining the role of phosphatidylinositol 4-phosphate and its impact on membrane protein localization, particularly the KRAS oncogene, the lab aims to uncover new insights into cellular signaling and potential vulnerabilities in cancer pathways. This research is critical for linking cellular metabolism to lipid regulation and offers implications for understanding and treating KRAS-driven cancers.

Dr. Madhavi P. Kadakia's lab focuses on understanding how certain proteins, specifically Np63 and TIP60, influence the behavior of squamous cell carcinoma (SCC), particularly in their ability to resist chemotherapy treatments like cisplatin. The research aims to uncover why SCC tumors often become resistant to such treatments and to explore new strategies that could help overcome this challenge. Their work is significant as it seeks to find better ways to treat head and neck cancers, ultimately improving patient outcomes.