Dr. Xiaodong Cheng's laboratory focuses on understanding and treating diabetic retinopathy (DR), a leading cause of vision loss among diabetics. The lab investigates the role of a protein called Epac1 in the development of DR and explores new therapeutic strategies that could improve patient outcomes. By combining genetic and pharmacological methods, the team aims to create innovative drugs targeting the underlying mechanisms of this condition.

Oleh Pochynyuk's lab at the University of Texas Health Science Center focuses on understanding how the kidneys regulate sodium levels and blood pressure, especially in the context of hypertension. They study a specific signaling pathway involving proteins called Epac1 and Epac2, which play important roles in sodium transport within the kidneys. By exploring how to effectively target these proteins with new drugs, the lab aims to develop better treatments for hypertension, a major health issue.

Dr. Catherine Denicourt's lab at the University of Texas Health Science Center in Houston focuses on understanding how modifications to transfer RNA (tRNA) influence the process of mRNA translation, especially under stress conditions. They study a specific enzyme involved in tRNA modification and its role in cellular responses to stress, aiming to uncover how these mechanisms affect gene expression and cellular health. This research may have significant implications for understanding diseases linked to tRNA dysfunction.