Dr. Xiaojiang S Chen's lab at USC focuses on studying a family of proteins called APOBEC, which have critical roles in the immune response against viruses like HIV. The lab explores how these proteins interact with nucleic acids and how viruses can evade these defenses, with the goal of developing new therapeutic strategies for treating viral infections and related cancers. Their work combines structural biology with molecular dynamics to understand these complex interactions.

Dr. Irene E Chiolo's lab focuses on understanding how cells repair DNA double-strand breaks (DSBs) that occur due to various environmental factors and normal cellular processes. Specifically, the lab studies repair mechanisms in a specialized part of the genome called heterochromatin, which is notoriously difficult to work with due to its complex structure. By investigating the movement and organization of repair sites, the lab aims to uncover the molecular machinery that protects the genome from instability, providing insights into cancer development and potential treatments.

Dr. Emily R. Liman's research lab focuses on understanding how taste receptors in mammals detect different tastes, particularly sour and salty flavors. The lab studies a specific channel called OTOP1, which plays a crucial role in sensing acids and high concentrations of salts. By exploring how OTOP1 functions, the research aims to develop new tools to enhance our understanding of taste and potentially improve dietary choices to help combat health issues like obesity and hypertension.

Dr. Cheng-Ming Chuong's lab at the University of Southern California focuses on understanding how skin develops and regenerates, particularly emphasizing the different characteristics of skin in various body regions. By studying chickens, which have distinct skin features, the lab aims to uncover the biological mechanisms that could lead to improved skin substitutes for patients with severe injuries. The research combines traditional techniques with advanced genomic technologies to explore how skin's structure and function are determined at both the genetic and epigenetic levels.

David Raichlen's research lab focuses on understanding how sedentary behavior affects brain health and the risk of developing Alzheimer's disease. By examining the relationship between how much time people spend sitting and their cognitive functions, the lab aims to uncover important factors that could help in preventing Alzheimer's disease. The lab uses large datasets like the UK Biobank to assess the impact of lifestyle changes on brain health in older adults.

Dr. David D. McKemy's lab at the University of Southern California focuses on how our body senses cold temperatures and the resulting pain that may occur. The research explores the mechanisms of cold sensitivity and how injury can heighten this sensation, as well as how these processes can be utilized for therapeutic purposes. Ultimately, the lab aims to understand the complex biology behind cold-induced pain to develop better treatments for conditions like chronic pain and allodynia.