Dr. Ira J. Blader's lab studies how certain protozoan parasites adapt to different oxygen levels in their environment, particularly focusing on Toxoplasma gondii. By understanding how these parasites sense and respond to oxygen, the lab aims to develop new therapies that could help treat diseases caused by these infections in vulnerable populations. The research combines genetics, biochemistry, and molecular biology to uncover the mechanisms that drive pathogen survival and virulence in hostile conditions.

Dr. Liwu Li's lab at Virginia Tech focuses on understanding the immune response during sepsis, a life-threatening condition caused by infections. The lab's research aims to uncover how certain immune cells, particularly exhausted monocytes, contribute to both inflammation and immune suppression, which worsens sepsis outcomes. By exploring molecular mechanisms and potential therapeutic targets, the team hopes to develop strategies to improve treatment and recovery for sepsis patients.

Kirsten Nielsen's lab at Virginia Tech focuses on understanding the interactions between the immune system and the fungus Cryptococcus neoformans, which can cause serious infections in people with weakened immune systems, especially those with HIV/AIDS. The research investigates how different strains of the fungus and the environment of the host impact disease outcomes. By exploring these interactions, the lab aims to develop new treatments that could help patients better manage their infections.