Dr. Benjamin J. Koestler's lab at Western Michigan University studies how bacteria survive acidic environments, particularly focusing on E. coli and Shigella. His team investigates the role of amino acids in helping these bacteria resist acid stress and the regulatory mechanisms involved, particularly the second messenger c-di-GMP. Their research has implications for human health as it aims to uncover new strategies to promote beneficial bacteria and mitigate harmful pathogens in our gastrointestinal systems.