Dr. Markus Bredel's lab focuses on understanding the mechanisms behind gliomas, a type of aggressive brain tumor that originates from neural progenitor cells. The research explores how specific genetic alterations, particularly involving the NFKBIA gene, influence chromatin structure and gene regulation during the development of these tumors. By studying these processes, the lab aims to identify potential therapeutic targets for gliomas and decipher how neural cell differentiation can lead to cancer.

Dr. Chun-Yuh Huang's lab at the University of Miami focuses on understanding the causes of intervertebral disc degeneration, a key contributor to low back pain, which affects millions of people. The lab investigates how factors like aging and inflammation impact the metabolism of disc cells and the production of essential components like proteoglycans. By combining laboratory experiments, patient studies, and computational models, the team aims to identify new therapeutic targets and improve diagnostic methods for disc degeneration.

Dr. Alan Pollack's lab at the University of Miami focuses on improving treatment outcomes for prostate cancer patients undergoing radiotherapy. They use advanced imaging techniques and liquid biopsies to identify early indicators of how well patients respond to treatment. This research aims to better tailor therapy for patients by integrating imaging data and circulating tumor cells into risk assessment models for more effective decision-making in cancer care.