Dr. Brian S. J. Blagg's lab at the University of Notre Dame is engaged in innovative cancer research focused on developing targeted therapies. The lab primarily investigates inhibitors of heat shock proteins and their potential to treat challenging cancers, particularly prostate cancer and glaucoma. By creating specific inhibitors that reduce side effects and enhance the effectiveness of existing treatments, the lab aims to improve outcomes for patients with these serious conditions.

Dr. Shahriar Mobashery's lab at the University of Notre Dame focuses on understanding how the bacterium Staphylococcus aureus becomes resistant to beta-lactam antibiotics, which are crucial for treating infections. The research aims to identify novel agents that could reverse this resistance and restore the efficacy of these antibiotics. The lab employs various techniques to study the genetic and molecular mechanisms involved in this antibiotic resistance.

Dr. Brian M Baker's lab at the University of Notre Dame focuses on understanding how mechanical forces influence T cell behavior in the immune system. The research involves studying the interactions between T cell receptors and peptide-MHC complexes, particularly how these interactions can change under different forces. By developing models to explain these interactions, the lab aims to manipulate T cell responses, which could lead to better strategies in immunotherapy and vaccine design.

Dr. Juan R Del Valle's research lab focuses on understanding tau protein, which is associated with neurodegenerative diseases affecting memory and cognitive function. The lab develops synthetic peptides that mimic the structure of misfolded tau to investigate how these proteins propagate in the brain and contribute to disease progression. Their innovative approach aims to generate tools that can help in the early diagnosis and treatment of these conditions.