Dr. Xue Gao's lab at the University of Pennsylvania focuses on advancing techniques for precise genome editing, particularly in the context of cardiac diseases like hypertrophic cardiomyopathy (HCM). Through innovative approaches, they are developing controllable base editors that aim to correct genetic mutations with minimal off-target effects, ultimately offering new potential treatments for various conditions. The research explores new methods of delivering these genetic tools to ensure effective and safe applications in living organisms.

The research lab led by Edward Steager focuses on creating innovative robotic systems for improving dental treatments, particularly in managing infections caused by oral biofilms. Using nanotechnology, the lab designs small robots that can precisely target and disrupt biofilms in hard-to-reach areas of the mouth, offering a potential breakthrough in dental medicine. The project aims to enhance the efficacy of dental procedures by combining robotics and biochemistry for better diagnostics and treatment.