Markus Grompe's lab focuses on innovative methods for delivering gene therapy specifically targeting the liver, which plays a key role in treating inherited and acquired diseases. They explore the potential of using the biliary duct system for more effective gene therapy administration, especially in patients with liver cirrhosis. Their research aims to improve treatment outcomes by minimizing side effects and enhancing the efficiency of gene delivery methods.

Dr. Mu-Shui Dai's lab at Oregon Health & Science University focuses on understanding how a protein called USP36 regulates the nucleolar RNA exosome, which is crucial for ribosome production in cells. The lab studies how disruptions in this regulation can lead to cancer, particularly breast cancer. By exploring the biochemical mechanisms behind this process, the lab aims to identify potential therapeutic targets for cancer treatment.

Dr. Rosalie C. Sears' lab at Oregon Health & Science University focuses on improving early detection methods for pancreatic cancer. The research aims to develop sensitive blood tests and advanced imaging techniques that can identify cancer in its early stages, particularly for high-risk populations. Additionally, the lab is dedicated to addressing community engagement and increasing screening participation among underrepresented groups.

Dr. Andrew Adey's lab at Oregon Health & Science University studies how DNA methylation affects the development of mammalian cells. By using advanced techniques, they create detailed maps of how this modification changes during the growth of embryos. Their research aims to understand the roles of DNA methylation in cell fate decisions and connections to developmental diseases, making their findings important for both biology research and medical applications.