Dr. Sabine Pellett's lab at the University of Wisconsin-Madison focuses on understanding Botulinum Neurotoxins (BoNTs), which are potent toxins capable of causing severe disease. The lab investigates how these toxins work at a molecular level, especially regarding their duration and potency, which are crucial for both therapeutic applications and understanding their risks as potential bioweapons. Through innovative experimental approaches, the team aims to develop better treatments and countermeasures against botulism and related disorders.

Dr. Vanessa Sperandio's lab at the University of Wisconsin-Madison studies how gut bacteria and host signals regulate disease-causing bacteria, specifically enterohemorrhagic E. coli (EHEC). The lab focuses on understanding how neurotransmitters like norepinephrine and endocannabinoids affect the virulence of these pathogens and their interactions with the gut microbiota. This research is important for understanding microbial infections and developing better treatments against enteric diseases.

Dr. Anna Huttenlocher's lab at the University of Wisconsin-Madison studies how cells move and communicate during the healing of wounds. They primarily use zebrafish as a model organism because of their clear bodies, which allow researchers to observe cellular interactions easily. The lab aims to understand the molecular mechanisms that regulate cell migration, which is crucial for repairing tissues and can provide insights into conditions like diabetes and autoimmune diseases.

The lab led by Dr. Laura J. Knoll at the University of Wisconsin-Madison focuses on understanding how the immune system responds to infections from protozoan parasites in the human gut. By developing advanced 3D microphysiological models that mimic the human intestinal structure, the lab aims to study the interactions between parasites and immune cells, which is crucial for designing effective vaccines against these infections. The research takes into account the complex environment of the gut, including conditions that affect immune responses.

Dr. John-Demian Sauer's lab focuses on understanding how the foodborne pathogen Listeria monocytogenes survives inside host cells. The research centers on the unique adaptations that allow these bacteria to thrive in the stressful environment of the cytosol — the liquid found inside cells. By identifying key genes and pathways that help Listeria respond to stress and utilize nutrients, the lab aims to uncover new insights into bacterial behavior and potentially inform public health strategies against infections.