Dr. Antoni Barrientos' lab at the University of Miami focuses on understanding the assembly of mitochondrial complexes, which are critical for energy production in our cells. The team studies how proteins of different origins come together to form these complexes and how disruptions in this process can lead to various diseases, including neurodegeneration and metabolic disorders. They utilize advanced techniques like gene editing and cryo-electron microscopy to uncover the molecular mechanisms behind mitochondrial biogenesis in both yeast and human cells.

Dr. Michael Benatar's research lab at the University of Miami focuses on understanding and preventing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The lab conducts a pioneering study called Pre-Symptomatic Familial ALS (Pre-fALS) that seeks to identify early markers of these diseases in individuals who are genetically at risk, with the aim of facilitating early intervention. By analyzing clinical data and biological samples, the lab aims to develop prevention strategies that can alter the course of these devastating neurodegenerative disorders before symptoms appear.

Dr. Lilah Besser's lab at the University of Miami focuses on understanding how urban environments, particularly heat exposure, affect cognitive health in older adults, especially those at risk for Alzheimer's disease and related dementias. The research aims to uncover the links between urban heat islands—areas with significantly higher temperatures due to human activity—and changes in cognitive function, brain structure, and dementia risk. By investigating the role of greenspaces in mitigating these effects, the lab seeks to inform public health interventions that promote healthier living environments.

Dr. Alberto Rafael Ramos's lab at the University of Miami focuses on understanding how sleep, specifically obstructive sleep apnea, affects cognitive decline and Alzheimer's disease risk in Latino communities. The research is crucial because Latinos have a much higher rate of Alzheimer's disease and related dementias compared to non-Hispanic whites. The lab aims to identify how vascular risk factors like blood pressure fluctuations relate to cognitive health in this population, potentially paving the way for prevention strategies.

Dr. Hannah Gardener's research lab focuses on understanding how exposure to certain harmful chemicals, known as PFAS, affects brain health, particularly in relation to cognitive decline and dementia. The lab is investigating how PFAS may influence lipid metabolism and vascular health, which are critical factors in the development of Alzheimer's disease. By studying diverse populations over long periods, the lab aims to shed light on the connections between these pollutants and neurodegenerative conditions, ultimately aiming to inform public health strategies.

Dr. Miguel A Perez-Pinzon's lab at the University of Miami focuses on understanding how ischemic preconditioning can protect the brain from stroke-related damage. They study the role of specific molecules like Brain-Derived Neurotrophic Factor (BDNF) and Resveratrol in improving brain function and synaptic health. The lab aims to uncover new therapeutic strategies to help patients recover cognitive function after a stroke and potentially benefit those with related conditions like Alzheimer's disease.