Dr. Cory Abate-Shen's research lab focuses on understanding the mechanisms of prostate cancer and bladder cancer progression. The lab employs advanced models, including genetically-engineered mice and patient-derived organoids, to investigate how specific genes and mitochondrial functions affect cancer development and metastasis. These studies aim to identify potential therapeutic targets for treatment.

Dr. Carla P. Concepcion's lab focuses on developing innovative therapies for a specific type of lung cancer that lacks effective treatments. Her research targets the SMARCA2 gene, which plays a critical role in the growth of tumors that have lost another important gene called SMARCA4. By studying genetically engineered mice, her team is investigating how to effectively degrade SMARCA2 to inhibit cancer development and exploring how the immune system can help in these treatments. This work aims to provide new hope for patients with this aggressive form of lung cancer.

Dr. Yonghao Yu's lab focuses on studying a specific protein modification called poly-ADP-ribosylation, which plays a critical role in how cells respond to stress and may be linked to neurodegenerative diseases like ALS and frontotemporal dementia. By using advanced techniques in mass spectrometry and bioinformatics, the lab aims to understand how this modification contributes to disease processes and potentially identify new therapeutic targets for treatment.