Dr. Heng Zhu's lab at Johns Hopkins University focuses on understanding how DNA methylation affects brain development and neurological disorders. They are particularly interested in a less-studied type of DNA methylation known as CpH methylation, which occurs in the neurons of the brain. The lab combines innovative techniques to identify proteins that bind to this type of methylation, aiming to elucidate their roles in transcriptional regulation and potentially uncover new therapeutic targets for conditions like fragile X syndrome and ALS.