Dr. Prasad V Katakam's lab focuses on understanding how brain microvessels (BMVs) contribute to impaired cognitive function in Alzheimer's disease (AD), particularly how they are affected by peroxynitrite and sex differences. Using advanced techniques, the lab studies mitochondrial function and energy production in BMVs from different mouse models to uncover potential therapeutic targets to improve neurological health.

The research lab led by Dr. Sarah Hoffmann Lindsey focuses on understanding how sex hormones like estrogen and testosterone affect cardiometabolic health in men and women. Their studies utilize innovative approaches to investigate the vascular responses to these hormones and aim to develop therapies that enhance cardiovascular protection while maintaining metabolic benefits. Through this work, they hope to improve treatment strategies for hormone therapy in patients.

Dr. Ibolya Rutkai-Green's lab at Tulane University focuses on understanding how aging affects the blood vessels in the brain. They study how reduced blood flow, especially in older mice, can lead to problems with the blood-brain barrier and increase the risk of neurodegenerative diseases like Alzheimer's. By combining advanced imaging techniques and various biological assays, the lab aims to uncover the mechanisms behind these vascular changes due to aging.