Dr. P Jeffrey Conn's lab at Vanderbilt University focuses on understanding how two specific proteins in the brain, mGlu3 and mGlu5, work together to improve learning and memory. By studying these interactions in rodent models, the lab aims to find new ways to enhance cognitive function and address cognitive deficits related to disorders like schizophrenia. Their research combines advanced techniques in genetics, pharmacology, and neurobiology to explore new treatments for these challenges.

Dr. Lisa Monteggia's research lab at Vanderbilt University focuses on understanding the molecular mechanisms behind rapid and sustained antidepressant effects, particularly those induced by the drug ketamine. The lab investigates how brain-derived neurotrophic factor (BDNF) and methyl-CpG binding protein 2 (MeCP2) contribute to these antidepressant actions at the synaptic level. This research aims to uncover new treatment strategies for depression that could lead to faster and more effective therapies.

Dr. Erin Calipari's research lab at Vanderbilt University investigates the brain mechanisms involved in addiction, particularly how drugs like cocaine and alcohol affect neural circuits and behavior. The lab studies the role of specific neurons in the nucleus accumbens and how molecular changes in these cells contribute to addiction-related behaviors. By exploring these mechanisms, they aim to identify new treatment strategies for addiction that could help minimize relapse and improve outcomes for those struggling with substance use disorders.

Dr. Vsevolod V. Gurevich's lab focuses on understanding the molecular interactions of a protein called arrestin-1 with rhodopsin, which is crucial for vision. Researchers in this lab study how different forms of rhodopsin affect arrestin-1 binding and explore ways to create modified versions of arrestin-1 that could help treat vision disorders related to defects in rhodopsin phosphorylation. The work involves a mix of molecular biology techniques and innovative labeling methods to discover new proteins that interact with arrestin-1.