Dr. Zhongjie Sun's lab focuses on understanding how aging affects kidney function and blood pressure, particularly through the role of exosomes derived from renal stem cells. They investigate how these tiny vesicles influence kidney health and contribute to conditions like hypertension as people age. The research aims to uncover new treatment strategies for kidney diseases and hypertension in the elderly.

Dr. Gabor J. Tigyi's lab focuses on discovering small molecules that can enhance the immune response against tumors by targeting a specific receptor called LPAR5, which inhibits the activity of cytotoxic T cells. By blocking this receptor, the lab aims to improve T cell activation and boost the body's ability to fight cancer. This research could lead to new treatments for immune-resistant cancers.

Dr. Jonathan H. Jaggar's lab focuses on understanding how endothelial cells regulate blood vessel functions and their role in cardiovascular diseases like hypertension. The lab studies a specific chloride channel called TMEM16A, which has uncertain physiological and pathological impacts. By using various advanced techniques, the lab aims to uncover important insights into how these channels function under normal conditions and how they might contribute to vascular dysfunction when altered, especially in disease states.

Dr. Gadiparthi N Rao's lab focuses on the mechanisms behind retinal neovascularization, particularly in the context of diabetic retinopathy. The research aims to understand how a protein called GRP78 influences the formation of abnormal blood vessels in the retina, which can lead to vision loss. By investigating these mechanisms, the lab seeks to identify new therapeutic targets for treating retinal diseases while minimizing damage to healthy tissues.

Dr. Radhakrishna Rao's lab focuses on understanding how substances like alcohol and radiation damage the intestines and the immune systems that protect them. They investigate the role of calcium channels and specialized cells in the intestines, hoping to develop new treatments for alcohol-related diseases and radiation injuries. By studying how these factors lead to inflammation and gut health issues, the lab aims to find ways to counteract these serious health threats.