Dr. Arlan G. Richardson's lab focuses on understanding the aging process by developing a unique rat model that mimics human genetic diversity. This research will help evaluate potential interventions that may extend lifespan and improve health in aging populations. By studying the effects of hormones like estradiol on aging, the lab aims to identify strategies that could enhance longevity and health in both male and female subjects.

Dr. Tiangang Li's research lab focuses on understanding how bile acids affect liver and gut health, particularly in the context of metabolic diseases. They are exploring a novel bile acid derivative, Gly--MCA, which may help alleviate bile acid toxicity and improve liver function in diseases characterized by bile duct injury. The lab is investigating how Gly--MCA works and its potential as a new treatment for conditions like primary biliary cholangitis and primary sclerosing cholangitis.

Dr. Karen R Jonscher's lab focuses on understanding how maternal obesity affects the health of offspring, particularly in relation to nonalcoholic fatty liver disease (NAFLD). Her research uses a unique model of olive baboons to study the impact of maternal diet and supplements, such as pyrroloquinoline quinone (PQQ), on fetal development and metabolic health. The goal is to find safe dietary strategies to prevent metabolic diseases that can occur in children born to obese mothers.