Dr. Michael J. Caplan's research focuses on understanding the mechanisms behind Autosomal Dominant Polycystic Kidney Disease (ADPKD), a genetic disorder that leads to kidney dysfunction. His lab investigates the role of a specific protein fragment from polycystin-1 in preventing cyst formation and maintaining kidney health. By exploring how this fragment interacts with cellular structures and metabolism, the lab aims to identify new therapeutic targets for treating ADPKD.