The lab of Dr. Seung-Wan Yoo at Johns Hopkins University focuses on understanding the interactions between HIV and methamphetamine use, and how these lead to increased neuroinflammation and cognitive impairments. By using advanced models like iPSC-derived microglia and humanized mice, the lab investigates the molecular mechanisms involved, particularly the role of a protein called MECOM. The ultimate goal is to identify potential therapeutic targets that can help mitigate neurological issues faced by individuals living with HIV and substance use disorders.