University of Utah · NeuroscienceCenter for Synaptic Communication
Jason D Shepherd · Salt Lake City, Utah
Research Focus
Dr. Jason D. Shepherd's lab at the University of Utah studies how brain cells communicate and change at the synapse—the connections between neurons—specifically focusing on the protein Arc, which plays a crucial role in learning and memory. The lab investigates how Arc forms virus-like structures that can carry genetic messages from one neuron to another, potentially impacting synaptic strength and memory formation. By understanding this process, the research aims to uncover new insights into the cognitive functions of the brain and the underlying mechanisms of various mental disorders.
Arc proteinsynaptic plasticityintercellular communicationmemory formationretrovirus-like capsidsextracellular vesiclesneuronal signalingAMPA receptors
Research Aims
5AIM 01Investigate the role of Arc protein in synaptic plasticity and memory.
AIM 02Explore the mechanisms of intercellular communication mediated by Arc.
AIM 03Analyze how Arc forms capsids for transporting RNA between neurons.
AIM 04Test the effects of Arc on AMPA receptor dynamics at synapses.
AIM 05Determine the implications of Arc function for neurodevelopmental and psychiatric disorders.
Skills the Lab Values
electrophysiologylive-imaging techniquescell cultureRNA extractionWestern blottingmolecular cloningtransfection methodsimmunohistochemistrydata analysis with Python
Output against the department
Publications75bottom 21% of dept.527th of 671
this lab
most publishedleast published
Citations10ktop 40% of dept.267th of 671
this lab
most citedleast cited
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