Case Western Reserve University · GeneticsBetaCell Genesis Lab
Yan Li · Cleveland, Ohio
Research Focus
Dr. Yan Li's lab focuses on understanding pancreatic beta-cell biology and its implications for diabetes. They study how variations in genetic factors, particularly the gene HNF1A, affect the development and function of these cells. By using advanced techniques like single-cell genomic analyses, they aim to develop better strategies for generating functional beta-cells from stem cells, which could be crucial for diabetes therapies.
HNF1Abeta-celldiabetessingle-cell genomicscell differentiation
Research Aims
3AIM 01Investigate HNF1A's role in beta-cell heterogeneity and diabetes risk.
AIM 02Develop a reliable differentiation protocol for generating functional beta-cells from pluripotent stem cells.
AIM 03Map the molecular differences during beta-cell differentiation across various human pluripotent stem cell lines.
Skills the Lab Values
single cell RNA sequencing (scRNA-seq)single cell ATAC sequencing (scATAC-seq)CRISPR genome editingstem cell culturegenomic data analysis
Output against the department
Publications1,179top 3% of dept.7th of 259
this lab
most publishedleast published
Citations26ktop 22% of dept.57th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.