Texas A&M University-College Station · BiochemistrySacchettini Lab
James C Sacchettini · College Station, Texas
Research Focus
Dr. James C. Sacchettini's lab focuses on improving tuberculosis treatment by exploring the mycobacterial cell wall, which is crucial for the bacteria's survival. The team investigates how to make existing antibiotics more effective by understanding and exploiting synergies between different drugs. Their ultimate goal is to develop new combination therapies that can overcome drug resistance and accelerate TB treatment.
tuberculosisdrug resistancecombination therapymycobacterial cell wallsynergistic inhibitors
Research Aims
5AIM 01Identify metabolic proteins in the mycobacterial cell wall that can enhance antibiotic effectiveness.
AIM 02Develop new chemical inhibitors targeting the mycobacterial cell wall.
AIM 03Investigate the mechanisms of drug synergy during tuberculosis infections.
AIM 04Test the efficacy of combination therapies in preclinical models.
AIM 05Design strategies that accelerate the development of tuberculosis treatments.
Skills the Lab Values
PCRchemical geneticshigh throughput screeningbiochemical assaysdrug designcell culturemouse modelsstructural biologygenomicsin vitro testing
Output against the department
Publications384top 13% of dept.52nd of 402
this lab
most publishedleast published
Citations31ktop 11% of dept.46th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.