Icahn School of Medicine at Mount Sinai · PharmacologyCardiac Genetics and Therapeutics Lab
Masayuki Yazawa · New York, New York
Research Focus
Dr. Masayuki Yazawa's lab focuses on developing new drugs to treat Timothy syndrome and other genetic heart conditions that cause dangerous heart rhythms. The research leverages innovative technologies and human-derived heart cells to create potential therapeutics. Through these efforts, the lab aims to better understand the molecular causes of these disorders and improve treatment options for affected patients.
Timothy syndromecardiac arrhythmiaSigma 1 receptorgenetic heart diseasesmall molecule therapeutics
Research Aims
5AIM 01Investigate the role of calcium channel dysfunction in cardiac arrhythmias.
AIM 02Design and synthesize new small molecules targeting the Sigma 1 receptor.
AIM 03Test the efficacy of novel therapeutics in human iPSC and rodent models.
AIM 04Explore the application of new drug candidates for common forms of long QT syndrome.
AIM 05Characterize the molecular mechanisms underlying Timothy syndrome.
Skills the Lab Values
cell culturehuman induced pluripotent stem cells (iPSC)animal modelselectrophysiologymedicinal chemistrydrug developmentbiological assayspharmaceutical sciencemolecular characterization
Output against the department
Publications61bottom 10% of dept.413th of 462
this lab
most publishedleast published
Citations7.0kbottom 49% of dept.236th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.