University of California-San Diego · ChemistryNanoplatforms and Immunotherapy Lab
Michael J Sailor · La Jolla, California
Research Focus
Dr. Michael J. Sailor's lab at UC San Diego focuses on creating advanced nanoplatforms that target macrophages to improve treatment for lung infections. They are particularly interested in developing immunotherapies that can enhance the body's ability to fight pathogens like bacteria and viruses, while minimizing harmful inflammatory responses. The lab’s research aims to deliver RNA therapeutics specifically to infected areas in the lungs, which could change how we treat severe infections such as pneumonia.
nanotechnologymacrophage targetingRNA therapeuticsimmunotherapypulmonary infectionspneumonialipid nanoparticlesfusions silicon nanoparticlesviral infectionsfungal infections
Research Aims
3AIM 01Develop a strategy for targeted delivery of therapy to infected macrophages in the lungs.
AIM 02Evaluate different nanoplatforms for their ability to deliver RNA therapeutics effectively.
AIM 03Test the therapeutic efficacy of the most promising nanoplatforms in vivo to combat pulmonary infections.
Skills the Lab Values
nanoparticle synthesismacrophage cultureRNA delivery systemsin vivo animal modelsfluorescence microscopyimmunofluorescence stainingflow cytometryin vitro cell assayspharmacokinetics studiespeptide design
Output against the department
Publications469top 19% of dept.41st of 216
this lab
most publishedleast published
Citations34ktop 12% of dept.25th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.