Northwestern University · BiologyShukla Immunology Lab
Vipul Shukla · Evanston, Illinois
Research Focus
Dr. Vipul Shukla's lab at Northwestern University focuses on understanding how specialized immune responses are regulated in germinal centers, where B cells evolve to produce effective antibodies. The research investigates the roles of specific protein complexes that remodel DNA to influence B cell behavior and maintain a balanced immune response. Ultimately, the work aims to uncover the mechanisms important for generating robust immunity and how inflammation might disrupt these processes.
Germinal CentersB cell differentiationBAF compleximmunological responseschromatin remodelingadaptive immunityinflammationantibody production
Research Aims
3AIM 01Elucidate the epigenetic control of GC B cell differentiation by Arid1a-cBAF activity.
AIM 02Examine the roles of inflammatory signatures associated with Arid1a loss in disrupting GC responses.
AIM 03Define altered immunological landscapes and their contributions to perturbed GCs upon Arid1a loss.
Skills the Lab Values
Cell cultureMolecular cloningFlow cytometryChromatin immunoprecipitationWestern blotRNA sequencingMicroscopyAnimal modelsBioinformaticsStatistical analysis
Output against the department
Publications39bottom 7% of dept.955th of 1,033
this lab
most publishedleast published
Citations611bottom 3% of dept.1,007th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.