Duke University · PharmacologyLeukemia Mechanisms Research Lab
G Greg Wang · Durham, North Carolina
Research Focus
Dr. G Greg Wang's lab at Duke University focuses on understanding the complex mechanisms driving aggressive forms of leukemia. The lab is particularly interested in how specific proteins, like EZH2 and NUP98, contribute to cancer development and how these proteins can be targeted for better treatment strategies. Current research explores innovative techniques like PROTACs to degrade oncogenic proteins and investigates the role of phase separation in chromatin organization and gene activation that leads to leukemia.
leukemiaEZH2NUP98oncogenesisphase separationchromatin loopingPROTACcancer therapy
Research Aims
5AIM 01Investigate the non-canonical oncogenic functions of EZH2 in leukemia
AIM 02Characterize the role of intrinsically disordered regions in NUP98-related oncogenesis
AIM 03Develop novel EZH2-targeting therapies using PROTAC technology
AIM 04Examine the impact of phase separation on chromatin organization in cancer cells
AIM 05Identify therapeutic strategies for treating MLL1-rearranged leukemias through innovative drug candidates.
Skills the Lab Values
cell culturemouse modelsdrug designCRISPRprotein degradation assaysmolecular cloninggene expression analysisflow cytometry3D chromatin structure analysis
Output against the department
Publications224top 36% of dept.167th of 462
this lab
most publishedleast published
Citations12ktop 32% of dept.149th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.