University of Virginia-Main Campus · PhysiologyCalcium Dynamics Lab
Ming-Feng Tsai · Charlottesville, Virginia
Research Focus
Dr. Ming-Feng Tsai's lab at the University of Virginia focuses on understanding how mitochondrial calcium transport proteins function. These proteins are crucial for many processes in cells, including energy production and cell death. By studying their molecular mechanisms, the lab aims to uncover how these proteins can be targeted for new therapies to treat conditions like heart failure and neurodegenerative diseases.
mitochondrial calcium transportcalcium signalingcell deathion transportbiophysical methodspharmacological modulation
Research Aims
5AIM 01Investigate the mechanisms by which the MICU3 subunit enhances mitochondrial calcium uptake.
AIM 02Characterize the roles and molecular properties of the MCUR1 subunit in the uniporter complex.
AIM 03Establish the kinetic properties of NCLX in ion transport.
AIM 04Explore how small molecules can regulate NCLX activity through oxidation.
AIM 05Test the hypothesis that Letm1 functions similarly to known antiporters in facilitating H+/Ca2+ exchange.
Skills the Lab Values
electrophysiologybiochemical assaysstructural biology techniquesliposome reconstitutioncell culturekinetic analysis
Output against the department
Publications158top 46% of dept.131st of 286
this lab
most publishedleast published
Citations16ktop 19% of dept.55th of 286
this lab
most citedleast cited
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