California Institute of Technology · ChemistryHsieh-Wilson Neurobiology Lab
Linda C Hsieh-Wilson · Pasadena, California
Research Focus
Dr. Linda C Hsieh-Wilson's lab at Caltech is investigating the roles of chondroitin sulfate glycosaminoglycans (CS GAGs) in the brain, focusing on their structure, functions, and effects on neuroplasticity and inflammation. The research aims to understand how specific chemical modifications of CS GAGs influence processes that are crucial for memory, healing, and neurodegenerative diseases like Alzheimer's and multiple sclerosis. Students in the lab will engage in both chemistry and neurobiology techniques to explore these important interactions.
chondroitin sulfateneuroplasticityneuroinflammationglycosaminoglycansaxon remyelinationextracellular matrixCNS injurychemical biologytherapeutic targets
Research Aims
5AIM 01Advance understanding of structure-function relationships of CS GAGs.
AIM 02Identify new functions for specific CS sulfation motifs affecting memory and immunity.
AIM 03Develop chemical tools to manipulate GAG-mediated processes.
AIM 04Investigate the impact of CS sulfation on immune cell behavior related to inflammation.
AIM 05Explore therapeutic strategies to control neuroinflammation and promote neuronal repair.
Skills the Lab Values
organic chemistrycell cultureanimal modelsimmunohistochemistryWestern blotgene editingsulfation analysisECM remodeling techniquesprotein purification
Output against the department
Publications132bottom 31% of dept.149th of 216
this lab
most publishedleast published
Citations8.6kbottom 48% of dept.112th of 216
this lab
most citedleast cited
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