University of Alabama at Birmingham · Biomedical EngineeringSong TREM2 Lab
Yuhua Song · Birmingham, Alabama
Research Focus
Dr. Yuhua Song's lab focuses on discovering new ways to treat Alzheimer's disease by targeting a specific protein called TREM2. By using both computational and experimental approaches, the lab aims to find existing FDA-approved drugs that can enhance TREM2's function and improve immune responses affected by Alzheimer's. This research could lead to more effective drug treatments for the disease.
Alzheimer's diseaseTREM2drug repositioningimmune activationallosteric modulation
Research Aims
3AIM 01Identify FDA-approved drugs that bind to TREM2 using virtual screening methods.
AIM 02Characterize how these drugs affect TREM2's function and immune activation.
AIM 03Investigate if drug interactions can compensate for the immune activity loss caused by Alzheimer's-related TREM2 variants.
Skills the Lab Values
computational drug screeningbiophysical validation techniquescell cultureexperimental designsignal transduction assays
Output against the department
Publications211bottom 49% of dept.304th of 595
this lab
most publishedleast published
Citations5.3kbottom 40% of dept.356th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.