New York University · BiologyTumor Microenvironment and Immune Regulation Lab
Jun Wang · New York, New York
Research Focus
Dr. Jun Wang's lab at New York University focuses on understanding the mechanisms by which certain proteins in the tumor microenvironment suppress the immune system's ability to fight cancer. They are particularly interested in the roles of Siglec-15 and FGL1, two proteins that can inhibit T cell responses and promote tumor growth. By studying these proteins, the lab aims to develop new immunotherapies that can improve treatment outcomes for cancer patients who do not respond well to existing therapies.
cancer immunologyimmunotherapytumor microenvironmentimmune checkpointsT cell regulation
Research Aims
5AIM 01elucidate the immune suppressive mechanism of Siglec-15 in the tumor microenvironment
AIM 02develop and test anti-Siglec-15 therapies
AIM 03understand the role of FGL1 in tumor immunity
AIM 04create new LAG-3 targeted immunotherapies
AIM 05identify effective biomarkers for immunotherapy responses
Skills the Lab Values
cell culturemouse modelsmonoclonal antibody developmentbattle line microscopyclinical trial design