WMCWeill Medical College of Cornell University · Biology
H3.3 Immune Regulation Lab
Steven Zvi Josefowicz · New York, New York
Research Focus
Dr. Steven Zvi Josefowicz's lab focuses on understanding how a specific histone protein, H3.3, influences the immune system's response to infection and inflammation. They study how varying levels of H3.3 can adjust the activity of genes involved in immune functions, particularly in cells like macrophages and B cells. By exploring these mechanisms, the lab aims to uncover fundamental insights into how immune responses can be finely tuned, which has implications for treating various diseases.
histone variantH3.3immune responseinflammationgene regulationtranscriptionepigeneticsmacrophagesB cellspathogen defense
Research Aims
3AIM 01Explore the impact of H3.3 levels on inflammatory gene transcription across immune cells.
AIM 02Identify gene enhancers and transcription factors that regulate H3.3 expression during immune stimulation.
AIM 03Investigate the molecular mechanisms by which H3.3 regulates transcription and chromatin modifications.
Skills the Lab Values
PCRCRISPR interferenceRNA sequencingchromatin immunoprecipitationtranscriptomic studiesmouse modelsin vivo infection modelsexonuclease digestionprecision run-on sequencingdata analysis
Output against the department
Publications58bottom 14% of dept.880th of 1,033
this lab
most publishedleast published
Citations12ktop 31% of dept.317th of 1,033
this lab
most citedleast cited
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