Yale University · NeuroscienceNeurodegeneration Research Lab
Jesse Cedarbaum · New Haven, Connecticut
Research Focus
Dr. Jesse Cedarbaum's research lab focuses on understanding and treating neurodegenerative diseases, particularly those related to synucleinopathies, like Parkinson's disease. The lab conducts clinical trials exploring the effectiveness of anti-TNF therapies to slow the progression of symptoms in patients with REM Sleep Behavior Disorder. By integrating advanced imaging techniques and immunological assessments, the team aims to uncover new insights into the inflammatory processes that may drive these disorders.
synucleinopathiesREM Sleep Behavior Disorderanti-TNF therapyneuroinflammationT-cell immunologyclinical trialsneuroimagingbiomarkerssingle-cell RNA sequencingdopamine transport
Research Aims
5AIM 01Assess the potential of anti-TNF (adalimumab) therapy to mitigate symptoms of synucleinopathies.
AIM 02Characterize immune cell populations in patients with REM Sleep Behavior Disorder using advanced genomics techniques.
AIM 03Evaluate brain metabolic activity and structural integrity in patients undergoing anti-TNF therapy.
AIM 04Investigate soluble markers of inflammation and neurodegeneration in blood and cerebrospinal fluid.
AIM 05Utilize digital health technologies to monitor motor and cognitive function in clinical trial participants.
Skills the Lab Values
clinical trial designimmunophenotypingsingle-cell RNA sequencingDopamine Transporter SPECT imagingFDG-PET imagingflow cytometrydata collectionbiological sample collectionstatistical analysiswearable health technology
Output against the department
Publications222top 33% of dept.221st of 671
this lab
most publishedleast published
Citations18ktop 23% of dept.156th of 671
this lab
most citedleast cited
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