University of Pittsburgh-Pittsburgh Campus · Biomedical EngineeringGreenberger Lab
Joel S Greenberger · Pittsburgh, Pennsylvania
Research Focus
Dr. Joel S. Greenberger's lab at the University of Pittsburgh focuses on innovative approaches to protect against radiation injuries, particularly the acute gastrointestinal syndrome caused by total body or partial body irradiation. The lab is pioneering the use of engineered probiotics to deliver therapeutic molecules that restore intestinal health and promote recovery. Their work aims to develop safe and effective treatments that could be used in emergency situations, such as nuclear accidents or cancer therapies.
radiation injurygastrointestinal syndromeprobioticsintestinal stem cellsgene transcriptionLactobacillus reuteriimmune modulationdrug deliverymicrobial therapeuticsradiation mitigation
Research Aims
3AIM 01Establish the mechanism by which LR-IL-22 mitigates radiation-induced gastrointestinal damage.
AIM 02Investigate how combining LR-IL-22 with probiotics enhances intestinal recovery.
AIM 03Develop a safe microbial therapy with improved efficacy for radiation exposure scenarios.
Skills the Lab Values
oral gavagecell culturemolecular cloninggene expression analysisanimal handlingimmunohistochemistryPCRbioinformaticscryo-preservation of cellsmicrobiome analysis
Output against the department
Publications766top 7% of dept.44th of 595
this lab
most publishedleast published
Citations27ktop 11% of dept.66th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.