Texas A&M University-College Station · BiologyNeuroprotective Therapies Unit
Doodipala Samba Reddy · College Station, Texas
Research Focus
Dr. Doodipala Samba Reddy's lab focuses on developing innovative treatments to counteract the harmful effects of nerve agents, particularly in the context of seizure management and brain protection. The primary research involves creating new hydrophilic neurosteroids that can effectively treat severe seizures that do not respond to current medications like midazolam. This research is particularly relevant for military and civilian safety during chemical warfare scenarios.
anticonvulsantsneurosteroidsnerve agentsstatus epilepticusbrain protectiondrug development
Research Aims
4AIM 01Synthesize and optimize novel hydrophilic neurosteroids for anticonvulsant effects.
AIM 02Determine the efficacy of lead drugs against nerve agent-induced seizures and brain damage.
AIM 03Confirm the effectiveness of a lead drug in different nerve agent scenarios.
AIM 04Optimize pharmacokinetics and safety of a lead drug for FDA submission.
Skills the Lab Values
synthesis of neurosteroidsbiopharmaceutical formulationanimal modelsGABA receptor assayspharmacokinetics optimizationmedical countermeasure evaluationneuroprotection studieselectroencephalography (EEG)safety assessment protocols
Output against the department
Publications223top 28% of dept.287th of 1,033
this lab
most publishedleast published
Citations10ktop 37% of dept.378th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.