WMCWeill Medical College of Cornell University · Genetics
Crystal Lab
Ronald G Crystal · New York, New York
Research Focus
Dr. Ronald G Crystal's lab focuses on understanding and developing innovative treatments for severe health conditions like Alzheimer's disease and early COPD. They explore the genetic factors and biological mechanisms of these diseases, aiming to create effective gene therapies and interventions. Their research has potential implications for improving the lives of patients with genetic predispositions to these conditions.
gene therapyAlzheimer's diseaseCOPDAPOE4biomarkerssmall airway epitheliumCNS deliveryclinical trialsbiological markers
Research Aims
5AIM 01Identify gene therapies to reduce Alzheimer's disease risk in APOE4 homozygotes.
AIM 02Evaluate the safety and efficacy of adeno-associated virus delivery of APOE2 variants.
AIM 03Characterize small airway cell differentiation in early COPD patients.
AIM 04Examine the roles of BMP4 and SPDEF in small airway epithelium pathology.
AIM 05Correlate small airway cell biology with clinical phenotypes in COPD.
Skills the Lab Values
mouse modelsgene editingAAV-mediated gene therapycell cultureclinical trial designbiomarker analysisRNA extractionPCRflow cytometry
Output against the department
Publications1,092top 4% of dept.11th of 259
this lab
most publishedleast published
Citations86ktop 6% of dept.16th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.