Vanderbilt University · PhysiologyEdgerton Lab
Dale S Edgerton · Nashville, Tennessee
Research Focus
Dr. Dale Edgerton's lab at Vanderbilt University focuses on understanding how high-fat and high-fructose diets disrupt glucose metabolism. Using a unique canine model, the lab investigates liver functions related to glucose production and processing in the context of metabolic disorders like diabetes. The goal is to identify mechanisms that can inform new strategies for treatment, especially for conditions stemming from modern dietary habits.
glucose metabolisminsulin resistancehepatic functionhigh-fat dietamino acid metabolismdiabetesnutrient signaling
Research Aims
4AIM 01Clarify how high-fat and high-fructose diets disrupt glucose metabolism.
AIM 02Explore the effects of insulin delivery methods on liver glucose function.
AIM 03Investigate the role of amino acids in liver metabolism during dietary changes.
AIM 04Determine glucagon's interaction with insulin in nutrient processing.
Skills the Lab Values
animal experimentationsurgical techniquesinsulin infusionblood samplingmetabolic analysisglucose tolerance testsdata collectionnutrient regulation studies
Output against the department
Publications96bottom 27% of dept.208th of 286
this lab
most publishedleast published
Citations2.8kbottom 21% of dept.225th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.