University of Chicago · BiologyAutoimmunity and Immune Regulation Lab
Peter Aidan Savage · Chicago, Illinois
Research Focus
Dr. Peter Aidan Savage's lab at the University of Chicago focuses on understanding the interactions between regulatory T cells and B cells, particularly in the context of autoimmune diseases. The lab investigates how specific subtypes of regulatory T cells can regulate self-reactive B cells, which are implicated in the development of autoimmune conditions. By exploring these immunological relationships, the lab aims to unveil mechanisms that maintain immune tolerance and prevent autoimmunity.
autoimmunityregulatory T cellsB cellsimmune toleranceself-reactive B cells
Research Aims
4AIM 01Identify B cell-dependent regulatory T cells at the clonal and polyclonal level.
AIM 02Define the pathways governing the development and homeostasis of these Treg cells.
AIM 03Determine the functional role of these Treg cells in regulating B cell responses.
AIM 04Identify self-peptide ligands recognized by B cell-dependent regulatory T cells.
Skills the Lab Values
single-cell RNA sequencingT cell receptor profilingmouse modelsimmunohistochemistrycell sorting
Output against the department
Publications62bottom 16% of dept.862nd of 1,033
this lab
most publishedleast published
Citations4.6kbottom 35% of dept.668th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.