Columbia University in the City of New York · NeuroscienceFusi Neurogenesis Lab
Stefano Fusi · New York, New York
Research Focus
Dr. Stefano Fusi's lab at Columbia University focuses on understanding how the dentate gyrus, a part of the hippocampus, contributes to cognitive functions like memory and learning, especially in the context of aging and diseases like Alzheimer's. The lab studies adult hippocampal neurogenesis, the process of generating new neurons in the brain, which decreases with aging and is associated with cognitive decline. By exploring this process through genetic and pharmacological approaches, they aim to discover new methods to restore memory function in older individuals.
adult hippocampal neurogenesismemory encodingpattern separationcognitive declineAlzheimer's disease
Research Aims
5AIM 01Investigate the role of adult hippocampal neurogenesis in memory functions.
AIM 02Test if increasing adult neurogenesis can improve cognitive discrimination in aging.
AIM 03Utilize advanced neural recording techniques to study dentate gyrus function.
AIM 04Collaborate with experts to explore pharmacological interventions for cognitive deficits.
AIM 05Uncover the mechanisms of pattern separation in the elderly.
Skills the Lab Values
neural recordingsgenetic manipulationpharmacological interventionsmouse modelscomputational modeling
Output against the department
Publications229top 32% of dept.214th of 671
this lab
most publishedleast published
Citations13ktop 30% of dept.203rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.