UMCUniversity of Massachusetts Chan Medical School · Biology
Walker Metabolism Lab
Amy Karol Walker · Worcester, Massachusetts
Research Focus
Dr. Amy Karol Walker's lab explores how cellular metabolism influences aging and stress responses. By investigating a specific molecule, S-adenosylmethionine (SAM), the lab aims to understand its role in gene regulation during stress and the aging process. They focus on how different enzymes related to SAM production affect these biological pathways, potentially revealing new insights into aging mechanisms.
metabolismagingstress responseDNA methylationS-adenosylmethioninegene expressionCaenorhabditis eleganscell signalingmethylation pathways
Research Aims
4AIM 01Investigate how SAM impacts gene expression under stress conditions.
AIM 02Uncover the mechanisms of SAM synthases in cellular metabolism.
AIM 03Identify the role of methylation in regulating the aging process.
AIM 04Study the physiological responses influenced by metabolic cycles.
Skills the Lab Values
molecular cloningcell cultureRNA interferencegenetic transcription analysisproteomicsanimal modelsmetabolic modelingPCRchromatin analysis
Output against the department
Publications60bottom 15% of dept.870th of 1,033
this lab
most publishedleast published
Citations2.9kbottom 22% of dept.809th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.