University of Colorado Denver/Anschutz Medical Campus · Biochemistry

Neuronal RNA Localization Lab

Jefferson Matthew Taliaferro · Denver, Colorado

Research Focus

The lab led by Dr. Jefferson Matthew Taliaferro focuses on understanding how RNA localization impacts neuron function and its misregulation in diseases like ALS. By investigating the RNA-binding protein TDP-43, which is crucial for transporting RNA within neurons, the lab aims to uncover the consequences of RNA mislocalization in neurological disorders. The research combines advanced techniques in live cell imaging and stem cell biology to explore fundamental cellular processes that have implications for developing new therapeutic strategies.

ALSRNA localizationTDP-43neurosciencestem cell differentiationDrosophilalive cell microscopyneurological diseases

Research Aims

AIM 01Investigate the role of TDP-43 in RNA localization within neurons.

AIM 02Identify mislocalized RNAs in motor neurons related to ALS.

AIM 03Elucidate the mechanism by which TDP-43 recognizes and transports RNA.

AIM 04Analyze locomotor and physiological defects in Drosophila models for RNA mislocalization.

AIM 05Develop novel techniques for observing RNA dynamics in living systems.

Skills the Lab Values

RNA sequencinglive cell microscopystem cell cultureDrosophila geneticsRNA transport assaystranscriptomic analysisimaging techniquesdata analysis with Pythonreporter gene assays

Output against the department

Publications3bottom 1% of dept.400th of 402

this lab

most publishedleast published

Citations0bottom 1% of dept.401st of 402

this lab

most citedleast cited

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