University of Michigan-Ann Arbor · BiologyLaboratory of Cell Division Dynamics
Ajit Joglekar · Ann Arbor, Michigan
Research Focus
Ajit Joglekar's lab explores how cells regulate their division, specifically focusing on a mechanism called the Spindle Assembly Checkpoint. By studying this checkpoint, the lab aims to understand why certain cancer cells mismanage chromosome segregation during cell division. The work involves both experimental techniques and mathematical modeling to uncover the dynamics of cell signaling and its implications for genome stability in cancer.
Spindle Assembly Checkpointcell divisionchromosome segregationcancer biologysystems biologygenome instabilitymathematical modelingsignal transductionkinetochoresanaphase delay
Research Aims
5AIM 01Investigate the signaling dynamics of the Spindle Assembly Checkpoint during cell division.
AIM 02Quantify the role of unattached kinetochores in generating anaphase inhibition signals.
AIM 03Develop a mathematical model to predict chromosome missegregation behavior in cancer cells.
AIM 04Assess the impact of aberrant checkpoint signaling on genomic stability.
AIM 05Explore the consequences of signaling perturbations on cancer cell biology.
Skills the Lab Values
cell culturemathematical modelingfluorescence microscopyWestern blotRNA sequencingquantitative data analysisexperimental designbioinformaticsprotein purificationlive-cell imaging
Output against the department
Publications77bottom 22% of dept.798th of 1,033
this lab
most publishedleast published
Citations3.4kbottom 25% of dept.770th of 1,033
this lab
most citedleast cited
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