University of California-Los Angeles · Microbiology & ImmunologyThe Immune Frontier Lab
Yvonne Yu-Hsuan Chen · Los Angeles, California
Research Focus
Dr. Yvonne Yu-Hsuan Chen's lab focuses on developing innovative immunotherapy approaches for treating glioblastoma multiforme (GBM), a highly aggressive brain tumor. The lab's key strategy is to engineer CAR-T cells that target specific tumor markers while also modifying the surrounding tumor environment to enhance immune response. Their work includes rigorous safety evaluations and aims to generate essential preclinical data to support clinical trials for GBM treatments.
glioblastomaCAR-T cell therapyimmunotherapytumor microenvironmentimmune response
Research Aims
5AIM 01Develop bispecific CAR-T cells targeting IL-13R2 and TGF-beta for GBM therapy.
AIM 02Evaluate the safety and efficacy of engineered CAR-T cells in preclinical models.
AIM 03Analyze immune composition and function in the GBM tumor microenvironment.
AIM 04Investigate the potential for epitope spreading using T-cell receptor sequencing.
AIM 05Generate preclinical data to support a phase-1 clinical trial for GBM treatment.
Skills the Lab Values
cell cultureflow cytometryimmuno-fluorescencesingle-cell RNA sequencingTCR sequencinganimal modelsbiopsy analysismultiplex immunoassaysgenetic engineering
Output against the department
Publications1bottom 1% of dept.479th of 486
this lab
most publishedleast published
Citations0bottom 1% of dept.478th of 486
this lab
most citedleast cited
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