UMCUniversity of Massachusetts Chan Medical School · Biology
Peterson Lab
Craig L Peterson · Worcester, Massachusetts
Research Focus
Dr. Craig L Peterson's lab at the University of Massachusetts Medical School focuses on understanding how the structure of chromosomes influences important cellular processes like gene expression, DNA replication, and repair. The lab investigates chromatin remodeling machines that play a critical role in maintaining genome stability and preventing diseases, including cancer. By using various experimental techniques, the lab aims to uncover the mechanisms behind chromatin dynamics and their implications for cellular function.
chromatin remodelinggene transcriptionDNA replicationchromosome dynamicsgenome stabilityATP-dependent enzymestranscriptional bufferingnoncoding RNA
Research Aims
5AIM 01Identify how ATP-dependent chromatin remodeling enzymes function in gene regulation.
AIM 02Investigate the role of the INO80C complex in maintaining genome stability.
AIM 03Explore mechanisms of transcriptional buffering during DNA replication.
AIM 04Determine how chromatin dynamics impact transcription of noncoding RNAs.
AIM 05Characterize the SWR1C remodeler and its influence on histone exchange.
Skills the Lab Values
PCRcell culturemass spectrometrycryogenic electron microscopygenomic sequencing fluorescence microscopybioinformaticsmolecular geneticsfluorescence-based assays
Output against the department
Publications247top 24% of dept.251st of 1,033
this lab
most publishedleast published
Citations24ktop 16% of dept.169th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.