Icahn School of Medicine at Mount Sinai · GeneticsKidney Development and Regulation Lab
Pin-Xian Xu · New York, New York
Research Focus
Dr. Pin-Xian Xu's research focuses on understanding kidney development and the role of specific transcription factors in this process. His lab investigates how Eya1 and its cofactors regulate gene expression during nephron formation, which is crucial for kidney function. The research aims to uncover how these regulatory mechanisms contribute to kidney diseases like Wilms tumor, which is common in children.
kidney developmenttranscription factorsnephron formationgene regulationWilms tumorcis-regulatory elementschromatin remodelingnephron progenitorsEya1
Research Aims
5AIM 01Investigate the regulatory networks controlled by Eya1 and its cofactors.
AIM 02Characterize Eya1 occupancy of cis-regulatory DNA elements in nephron progenitors.
AIM 03Explore the interaction between Eya1 and chromatin remodeling complexes.
AIM 04Identify Eya1-regulated genes and their functions in kidney disease.
AIM 05Examine the role of REST complex in gene repression in nephron progenitors.
Skills the Lab Values
ChIP-seqgene expression analysischromatin analysiscell cultureprotein-protein interaction studiesRNA extractionmolecular cloningWestern blotbioinformatics
Output against the department
Publications71bottom 17% of dept.212th of 259
this lab
most publishedleast published
Citations6.1kbottom 32% of dept.176th of 259
this lab
most citedleast cited
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